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1.
Fernando Bento Cunha Karina Torres Pomini Ana Maria de Guzzi Plepis Virgínia da Conceio Amaro Martins Eduardo Gomes Machado Renato de Moraes Marcelo de Azevedo e Souza Munhoz Michela Vanessa Ribeiro Machado Marco Antonio Hungaro Duarte Murilo Priori Alcalde Daniela Vieira Buchaim Rogrio Leone Buchaim Victor Augusto Ramos Fernandes Eliana de Souza Bastos Mazuqueli Pereira Andr Antonio Pelegrine Marcelo Rodrigues da Cunha 《Molecules (Basel, Switzerland)》2021,26(6)
Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the bone repair process in critical size defects in rat calvaria. The animals (Wistar rats, n = 30) were submitted to a surgical procedure to create the bone defect and were divided into three groups: Control Group (CG, n = 10), defects filled with blood clot; E24/37 Group (E24/37, n = 10), defects filled with bovine elastin matrix hydrolyzed for 24 h at 37 °C and C24/25 Group (C24/25, n = 10), defects filled with porcine collagen matrix hydrolyzed for 24 h at 25 °C. Macroscopic and radiographic analyses demonstrated the absence of inflammatory signs and infection. Microtomographical 2D and 3D images showed centripetal bone growth and restricted margins of the bone defect. Histologically, the images confirmed the pattern of bone deposition at the margins of the remaining bone and without complete closure by bone tissue. In the morphometric analysis, the groups E24/37 and C24/25 (13.68 ± 1.44; 53.20 ± 4.47, respectively) showed statistically significant differences in relation to the CG (5.86 ± 2.87). It was concluded that the matrices used as scaffolds are biocompatible and increase the formation of new bone in a critical size defect, with greater formation in the polymer derived from the intestinal serous layer of porcine origin (C24/25). 相似文献
2.
Dong Zheng Fu-Quan Wang Yuan-Guang Li Liang-Hong Guo Jing Cheng 《Analytica chimica acta》2004,508(2):225-231
Optimized combination of chemical agents was selected for sensitive electrochemical detection of dissolved ruthenium tris-(2,2′-bipyridine) (Ru-bipy). The detection was based on the chemical amplification mechanism, in which the anodic current of a redox-active analyte was amplified by a sacrificial electron donor in solution. On indium-doped tin oxide (ITO) electrodes, electrochemical reaction of the analyte was reversible, but that of the electron donor was greatly suppressed. Several transition metal complexes, such as ferrocene and tris-(2,2′-bipyridine) complexes of osmium, iron and ruthenium, were evaluated as model analyte. A correlation between the amplified current and the standard potential of the complex was observed, and Ru-bipy generated the largest current. A variety of organic bases, acids and zwitterions were assessed as potential electron donor. Sodium oxalate was found to produce the largest amplification factor. With Ru-bipy as the model analyte and oxalate as the electron donor, the analyte concentration curve was linear up to 50 μM, with a lower detection limit of approximately 50 nM. Preliminary work was presented in which a Ru-bipy derivative was attached to bovine serum albumin and detected electrochemically. Although the combination of Ru-bipy, oxalate and ITO electrode has been used before for electrochemiluminescent detection of Ru-bipy and oxalate, as well as electrochemical detection of oxalate, its utility in amplified voltammetric detection of Ru-bipy as a potential electrochemical label has not been reported previously. 相似文献
3.
Yu. Satov B. Sharkov H. Haseroth Yu. Smakovski K. Makarov S. Kondrashev V. Roerich A. Stepanov H. Kugler R. Scrivens O. Camut A. Shumshurov A. Balabaev A. Charushin 《Journal of Russian Laser Research》2004,25(3):205-216
Experimental and numerical calculation results devoted to development of an optical system for an ion source based on a repetition rate CO2 laser are described. The laser chain consists of a master oscillator, gas absorber cells, and a four-pass amplifier. The optical system provides smooth laser pulses with variable duration and high spatial quality that ensures efficiency for plasma heating and ion generation. The parameters of the plasma ion component measured in the CERN laboratory are applied for a lead target illumination. 相似文献
4.
介绍了一台10mm口径两级双程离轴放大系统,实现了对5mm×5mm口径光束的激光放大,耦合系统采用高功率LDA紧密侧面直接抽运棒状Nd:YLF方式。分析并实验研究了在不同抽运电流、放大脉冲与放大器LDA抽运时刻的不同延时及不同注入能量条件下,放大系统及光束每次放大时放大特性的规律。实验得到:在放大系统5mm×5mm软光阑处注入1.58mJ能量时,放大系统可输出129.2mJ能量,能量提取效率达到19.5%,满足该系统的设计指标。 相似文献
5.
光参量啁啾脉冲放大(OPCPA)在饱和放大区存在一个增益稳定点,据此设计了一个输出稳定的三级OPCPA系统;第一、二、三级分别选用准相位匹配的周期极化钛氧磷酸钾(PPKTP)晶体、LBO晶体和KDP晶体作为增益介质。饱和放大时,增益随泵浦光强度变化时的增益输出稳定性明显改善,在泵浦光强度抖动低于6%的情况下,各级光参量放大器OPA输出的增益抖动小于1%。前级采用准相位匹配的PPKTP晶体作为增益介质,在远低于破坏阈值的30MW/cm2的泵浦功率密度下,可得到2×105的饱和放大增益和20%的能量转换效率。 相似文献
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The influence of the parameter of amplitude-phase coupling for nonlinear amplification on the phase-frequency characteristics of an injection laser in the regime of pumping current modulation has been investigated theoretically. The parameter is defined as the coefficient of proportionality between changes in the real and imaginary parts of the refractive index during variation of the density of photons in the cavity. The substantial dependence of the coefficient of phase modulation on the parameter of the amplitude-phase coupling for nonlinear amplification at small modulation frequencies is shown. A technique to determine the indicated parameter based on the frequency dependence of the ratio between the coefficients of phase and amplitude modulation is suggested. 相似文献
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回热器是脉管制冷机的关键部件之一,其效率对脉管制冷机性能有很大影响。铅丸是常见的蓄冷材料,通常用于回热器的低温端。本文测试和分析了不同品质的国产铅丸和进口铅丸对单级G-M型脉管制冷机性能的影响。采用额定功率为6.0 kW的压缩机驱动,使用进口铅丸脉管制冷机最低制冷温度达12.9 K,这是当前单级脉管制冷机达到的最低制冷温度;40 K时的最大制冷量为57.4 W。使用国产铅丸最低制冷温度为13.6 K,40 K时的最大制冷量为55.9 W。本文对低温制冷机蓄冷材料选择具有一定的参考价值。 相似文献